Endocrine Abstracts

Developmental programming of insulin resistance in the offspring of diabetic mothers have contributed significantly to the increased prevalence of type 2 diabetes mellitus and other metabolic disorders in the general population. Vitamin D has been reported to improve glucose metabolism, however its potential in reversing glucose intolerance programmed in the offspring of diabetic mothers has not been fully elucidated. The study therefore aimed to investigate the effect of vita...

Polycystic ovarian syndrome (PCOS) is a common endocrine and gynaecological disorder, occurring in 5% to 20% women of reproductive age. It is characterized by hyperandogenism, ovulatory dysfunction and polycystic ovaries. Impaired hypothalamic-pituitary-ovarian axis, insulin resistance and oxidative stress are identified causal mechanisms of PCOS. Vernonia amydalina(VA) leaf is a medicinal plant containing bioactive phytochemicals known to improve insulin sensitivity....